Biography
After obtaining a Master's degree in Pharmaceutical Sciences in 2002, Jean-Michel Rabanel worked for several years as a research assistant and in laboratory design at the Universit茅 de Montr茅al's Faculty of Pharmacy. After obtaining a PhD in Pharmaceutical Sciences in 2015, focusing on the physicochemical properties of polymeric drug carriers, he completed a postdoctoral fellowship at INRS Centre Armand Frappier in the laboratory of Prof. C. Ramassamy, working on the themes of brain delivery in the context of Alzheimer's disease and the protection of natural antioxidants. More recently, working in the laboratory of Pr X. Banquy's laboratory at the Universit茅 de Montr茅al, he focused on the potential of molecular brushes for brain delivery and nucleic acid encapsulation.
Expertise
- Galenics
- Physicochemical properties of active ingredients
- Properties and roles of polymers in pharmaceutical sciences
- Characterization of nanomaterials for pharmaceutical applications
Research Projects
Jean-Michel Rabanel's research has focused on nanotechnologies applied to improving the delivery of active ingredients, particularly polymer-based delivery systems. In particular, he has studied the relationship between polymer architecture and function when assembled into nano-objects, i.e. interactions with biological media, entry into cells, crossing of biological barriers, biodistribution in model organisms and release of active ingredients.
Publications
- Rabanel*, J.-M. , Mirbagheri*, M., Olszewski, M., Xie, G., Le Goas, M., Latreille, P.-L., Counil, H., Herv茅, V., Oliveira Silva, R., Zaouter, C., Adibnia, V., Acevedo, M., Servant, M. J., Martinez, V., Patten, S. A., Matyjaszewski, K., Ramassamy, C., Banquy. X. (2022). Deep tissue penetration of bottle-brush polymers via cell capture evasion and fast diffusion. ACS Nano, 16(12), 21583鈥21599.
- Latreille, P.-L., Rabanel, J.-M., Le Goas, M., Salimi, S., Arlt, J., Patten, S. A., Ramassamy, C., Hildgen, P., Martinez, V. A., Banquy, X. (2022). In situ characterization of the protein corona of nanoparticles in vitro and in vivo Advanced Material, 2203354.
Delbreil, P., Rabanel, J.-M., Banquy, X., Brambilla, D. (2022). Therapeutic nanotechnologies for Alzheimer鈥檚 disease: a critical analysis of recent trends and findings. Advanced Drug Delivery Reviews, 114397. - Le Goas, M., Saber, J., Gonzales Bolivar, S., Rabanel, J.-M., Awogni, J.-M., Boffito, , D. C., Banquy, X. (2022). (In)stability of ligands at the surface of inorganic nanoparticles: a forgotten question in nanomedicine? Nano Today, 45, 101516.
- Rabanel, J.-M., Faivre, J., Zaouter, C., Patten, S. A., Banquy, X., Ramassamy, C. (2021). Nanoparticle shell structural cues drive in vitro transport properties, tissue distribution and brain accessibility in zebrafish, Biomaterials, 277, 121085.
- Haddad, H., Herv茅, V., Ben Khedher, M. R., Rabanel, J.-M., Ramassamy, C. (2021). Glutathione: an old and small molecule with great functions and new applications in the brain and in Alzheimer鈥檚 disease, Antioxid. Redox Signal, 35 (4), 270-292.
- Rabanel, J.-M., Piec, P.-A., Landri, S., Patten, S. A., Ramassamy, C. (2020). Transport of PEGylated-PLA nanoparticles across blood brain barrier models and entry into neuronal cells: new insights from systematic study鈥, Journal of Controlled Release, 328, 679-695.
- Rabanel*, J.-M., Delbreil*, P., Banquy, X., Brambilla, D., Ramassamy, C. (2020). Periphery-confined particulate systems for the management of neurodegenerative diseases and toxicity: avoiding the Blood-Brain-Barrier challenge Journal of Controlled Release, 322, 286-299.
- Charabati*, C., Rabanel*, J.-M., Ramassamy C., Prat, A. (2020). Overcoming the brain barriers: from Leukocytes to nanoparticles; Trends in Pharmaceutical Sciences, 41, 42-54.
- Latreille, P.-L., Adibnia, V., Nour, A., Rabanel, J.-M., Lalloz, A., Arlt, J., Poon, Hildgen, P., Martinez, V. A., Banquy, X. (2020). Spontaneous Shrinking of Soft Nanoparticles Boosts their Diffusion in Confined Media; Nature Communication, volume 10, Article number: 4294.
- Rabanel, J.-M., Perrotte, M., Ramassamy, C. Nanotechnology at the Rescue of Neurodegenerative Diseases: Tools for Early Diagnostic, Dans Nanobiotechnology in Neurodegenerative Diseases, Rai, M., Yadav, A. (Eds). 2019: Springer Nature.
- Rabanel, J.-M., Djiokeng Paka, G., Ramassamy, C. Polymeric nanoparticles as vehicle for delivery of antioxidants in the brain. Potential application Dans Neurodegenerative diseases in Biomedical Application of Nanoparticles, Rihn, B. H. 2017: CRC Press by Taylor and Francis Group.
Awards and Nominations
- Postdoctoral Fellow, Institut TransMedTech (2020-2021), Apogee Canada Research Excellence Fund
- Postdoctoral Fellow (2017-2019), NSERC-CRSNG
- Postdoctoral Fellow (2016-2017), Fonds de recherche du Qu茅bec - Nature et technologies
- Prize for the best thesis in Health Sciences (2016), Universit茅 de Montr茅al
- Rector's Honour List (2016), Universit茅 de Montr茅al
- Sandoz Canada Inc. award (2012), Excellence in research for a graduate student
- Doctoral Scholarship (2011-2013), Fonds de recherche du Qu茅bec - Nature et technologies