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Biography

Medical School

• University of Ottawa (2024)

Residency

• RCPSC Emergency Medicine, University of Ottawa

Personal Interests/Personal Philosophy or Quote

• Baking
• Cooking
• Painting
• Hiking
• Travel
• “The future belongs to those who believe in the beauty of their dreams” - Eleanor Roosevelt

Publications

• Chehade, L., Deguise, M-O., De Repentigny, Y., Yaworski, R., Beauvais, A., Gagnon, S., Hensel, N. & Kothary, R (2022). Suppression of the necroptotic cell death pathways improves survival in Smn2B/− mice. Frontiers in Cellular Neuroscience.16: 972029. .
• Chehade, L., Khouri, H., Malatier-Ségard, J., Caron, A., Mauger, J-F., Chapados, NA. & Aguer, C (2022). Acute exposure to environmentally relevant levels of DDT alters muscle mitochondrial function in vivo in rats but not in vitro in L6 myotubes: A pilot study. Toxicology Reports. 9, 487–498. .
• Reilly, A., *Chehade, L., & Kothary, R. (2022). Curing SMA: Are we there yet?. Gene therapy. 30, 8-17. .
• Deguise, M. O., *Chehade, L., & Kothary, R. (2021). Metabolic Dysfunction in Spinal Muscular Atrophy. International Journal of Molecular Sciences. 22(11):5913. .
• Ahmed, F., *Chehade, L., Garneau, L., Caron, A., & Aguer, C. (2020). The effects of acute BPA exposure on skeletal muscle mitochondrial function and glucose metabolism. Molecular and Cellular Endocrinology. 499: 110580. .
• *Chehade, L., Caron, A., & Aguer, C. (2016). Role of Environmental Pollutants in Skeletal Muscle Insulin Resistance and Mitochondrial Dysfunction. Environment and Natural Resources Research, 6 (4), 60-78. .
• Pietrobon, A., Chehade, L., Beaudry-Richard, A., Keller, B. A., & Schlossmacher, M. G. (2020). Performance report for a 10-year-old MD/PhD Program: A survey of trainees at the University of Ottawa. Clinical and Investigative Medicine. 43(2): E1–E13. .
• Deguise, M. O., Chehade, L., Tierney, A., Beauvais, A., & Kothary, R. (2019). Low fat diets increase survival of a mouse model of spinal muscular atrophy. Annals of Clinical and Translational Neurology. 6(11), 2340–2346. .
• Khayrullina, G., Alipio‐Gloria, Z. A., Deguise, M., Gagnon, S., Chehade, L., Stinson, M., Belous, N., Bergman, E. M., Lischka, F. W., Rotty, J., Dalgard, C. L., Kothary, R., Johnson, K. A., & Burnett, B. G. (2022). Survival motor neuron protein deficiency alters microglia reactivity. Glia. 70(7), 1337-1358. .
• Deguise, M. O., Pileggi, C., De Repentigny, Y., Beauvais, A., Tierney, A., Chehade. L., Michaud, J., Llavero-Hurtado, M., Lamont, D., Atrih, A., Wishart, T. M., Gillingwater, T. H., Schneider, B. L., Harper, M. E., Parson, S. H., & Kothary, R. (2021). SMN Depleted Mice Offer a Robust and Rapid Onset Model of Nonalcoholic Fatty Liver Disease. Cell Mol Gastroenterol Hepatol. 12(1):354-377.e3. 10.1016/j.jcmgh.2021.01.019.
• Deguise, M. O., de Repentigny, Y., Tierney, A., Beauvais, A., Michaud, J., Chehade, L., Thabet, M., Paul, B., Reilly, A., Gagnon, S., Renaud, J. M., & Kothary, R. (2020). Motor transmission defects with sex differences in a new mouse model of mild spinal muscular atrophy. EBioMedicine. 55: 102750. .
• Liwak-Muir, U., Dobson, C. C., Naing, T., Wylie, Q., Chehade, L., Baird, S. D., Chakraborty, P. K., & Holcik, M. (2016). ERK8 is a novel HuR kinase that regulates tumour suppressor PDCD4 through a miR-21 dependent mechanism. Oncotarget. 7(2), 1439–1450. .

Awards

• CIHR Vanier Canada Scholarship